Genomic Data Analyst - Molecular Biology

Company Description

One of Canada's Best Diversity Employers and Greater Toronto's Top Employers for many consecutive years, William Osler Health System (Osler) provides a safe and supportive health care network to grow your career. Osler is nationally recognized for its commitment to patient safety and is Accredited with Exemplary Standing, the highest rating a Canadian hospital can receive. As a major Ontario hospital system, and home to some of the biggest specialty and emergency departments in the country, Osler serves the 1.3 million residents of Brampton, Etobicoke and surrounding communities. We are proud to offer you incredible exposure to best-in-class health care delivery and challenging hands-on opportunities to stay at the top of your game.

A hospital system built for and by the community, we continue to expand our services to meet the needs of a growing population, creating opportunities for increased hands-on skills development, cross-department training and promotional opportunities. Guided by our accomplished senior leadership team, together we are driving our vision of patient-inspired health care without boundaries.

At Osler, we invest in careers that go beyond where health care professionals like you can achieve their goals and find deep personal and professional fulfillment. Join our team today!

Job Description

The Genomic Analyst position is a full-time position and is a staff member of the Advanced Diagnostics team. The Genomic Analyst will work with pathologists/hematopathologists and medical laboratory technologists/assistants within the Division of Advanced Diagnostics and wider Laboratory Medicine Department to provide comprehensive somatic genetic testing and reporting for solid tumours and hematological malignancies. This position will combine understanding and expertise in genetics/genomics, bioinformatics and biomedical research. The Genomic Analyst will serve as a subject matter expert in genetics and genetic variant interpretation as well as providing technical expertise in bioinformatics pipeline management, optimization and troubleshooting in addition to various other related duties as required.

Accountabilities:

• Manage the regular review, interpretation, and analysis of genetic variant data from next-generation sequencing (NGS) and qPCR testing
• Draft reports in partnership with medical staff (pathologists/hematopathologists) to provide data for the generation of clinical reports
• Serve as the primary resource of subject matter expertise and technical content for managers, directors, and lab medicine clinicians
• Analyze NGS data, create, manage, and optimize bioinformatic pipelines and troubleshoot errors
• Collaborate and coordinate with support personnel from ThermoFisher/sequencing technology vendor for technical troubleshooting and problem resolution
• Manage relevant computing resources such as data storage in partnership with the Osler information technology system team(s)
• Participate in the development, analysis, evaluation, and implementation of new genetic assays and/or technologies
• Troubleshoot and resolve issues related to software used to detect and interpret clinical significance of sequence and copy number variants (e.g. Ion Reporter, Alamut)
• Completion of validation documentation and operating procedures for new tests prior to implementation
• Ongoingly participate in continuing education initiatives as well as supporting quality assurance or research projects
• Preparation and editing of figures, presentation slides, posters and/or manuscript writing for external audiences
• Assist in writing protocols, standard operating procedures, and reports/report templates for the use of NGS and related technologies in clinical testing
• Participate in the preparation of policies, processes and procedure within the quality system to ensure effective operation/compliance with IQMH laboratory accreditation requirements
• Attend and contribute to staff meetings

Qualifications

• Master’s Degree in medical genomics
• Experience working with next-generation sequencing data: sequencing quality control, sequence alignment, variant calling and annotation, RNA-sequencing analysis, germline and somatic mutational events, copy number variants etc.
• Proven experience developing NGS bioinformatics pipelines
• Experience with relevant public databases
• Excellent written and communication skills
• Experience writing and editing scientific materials for external audiences
• Timely completion of tasks by adjusting priorities as required
• Proven excellence working in a team environment with strong interpersonal,
• Communication and conflict resolution skills
• Must demonstrate Osler's Values of Respect, Excellence, Service, Compassion, Innovation and Collaboration

Additional Information

Hours: Currently days/evenings/nights including weekends and statutory holidays (subject to change in accordance with operational requirements)

Internal application deadline: April 2, 2024

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Osler values inclusivity and diversity in the workplace. We welcome and encourage applicants from diverse backgrounds. We are committed to providing accessible employment practices that are in compliance with the Accessibility for Ontarians with Disabilities Act. If you require an accommodation at any stage of the recruitment process, please notify Human Resources at human.resources@williamoslerhs.ca.

While we thank all applicants, only those selected for an interview will be contacted. Any information obtained during the course of recruitment will be used for employment recruitment purposes only, and not for any other purpose.